Description

Fmoc-[15N]Tyr-Oh is a stable isotope-labeled derivative of the amino acid tyrosine, specifically modified with a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the α-amino group. This compound is essential for advanced research in proteomics and peptide chemistry, where precise isotopic labeling is required for mass spectrometry-based quantification and structural elucidation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs specializing in peptide synthesis and metabolic studies.

Application

• Stable Isotope Labeling in Quantitative Proteomics (SILAC, AQUA): Used as a heavy-labeled internal standard for accurate mass spectrometric quantification of peptides and proteins.
• Peptide Synthesis (Solid-Phase & Solution-Phase): Serves as a key building block for the incorporation of 15N-labeled tyrosine residues into custom peptides for research and drug discovery.
• Metabolic Pathway Tracing: Employed in studies to track tyrosine metabolism and incorporation into biological molecules within cell cultures or model organisms.
• NMR Spectroscopy Studies: Provides a 15N-enriched probe for nuclear magnetic resonance (NMR) analysis of peptide structure, dynamics, and interactions.
• Biomarker Discovery and Validation: Integral to developing targeted mass spectrometry assays for the detection and validation of disease-related peptides and post-translational modifications.
• Production of Labeled Reference Materials: Used to synthesize certified reference standards for clinical diagnostics and regulatory bioanalysis.

Basic Information

Product Name	Fmoc-[15N]Tyr-Oh
CAS No.	125700-34-7
Molecular Formula	C24H2015NNO5
Molecular Weight	~419.43 g/mol (for 15N isotopologue)
Synonyms	Fmoc-L-tyrosine(15N); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tyrosine(15N); Fmoc-Tyr(15N)-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-hydroxyphenyl)(15N)propanoic acid; Fmoc-15N-tyrosine; Fmoc-L-tyrosine-15N; Nα-Fmoc-L-tyrosine(15N)
EINECS	Contact for details

Quality Control

Our Fmoc-[15N]Tyr-Oh is manufactured under strict quality systems to ensure high isotopic and chemical purity for sensitive research applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, isotopic enrichment (>98 atom % 15N), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing these specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
15N Isotopic Enrichment	≥ 98 atom %
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.