Description

Chloramphenicol-[Ring-3,5-3H] is a tritium-labeled derivative of the broad-spectrum antibiotic chloramphenicol, specifically radiolabeled on the aromatic ring. This compound is essential for advanced pharmacokinetic, metabolic, and environmental fate studies, providing the high-sensitivity detection required for trace-level analysis. It is a critical tool for researchers and scientists in pharmaceutical development, agricultural chemistry, and environmental toxicology who require precise radiotracer technology.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of chloramphenicol and related compounds in biological systems.
• Environmental Fate and Ecotoxicity Research: Investigating the degradation, persistence, and bioaccumulation of chloramphenicol in soil and water systems.
• Mechanistic Biochemical Research: Studying the molecular binding interactions and inhibition mechanisms of chloramphenicol with bacterial ribosomes and other targets.
• Analytical Method Development: Serving as an internal standard or tracer in the development and validation of highly sensitive LC-MS/MS or scintillation counting methods.
• Veterinary Pharmaceutical Research: Exploring the metabolism and residue depletion profiles in food-producing animals.

Basic Information

Item	Details
Product Name	Chloramphenicol-[Ring-3,5-3H]
CAS No.	125440-98-4
Molecular Formula	C11H12Cl2N2O5 (3H)2
Molecular Weight	~ 323.13 g/mol (unlabeled) + 3H
Synonyms	Chloramphenicol (ring-3,5-3H); D(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide (ring-3,5-3H); [3,5-3H]Chloramphenicol; Tritiated Chloramphenicol; Chloromycetin-3H; Radioactive Chloramphenicol Tracer
EINECS	Contact for details

Quality Control

Every batch of Chloramphenicol-[Ring-3,5-3H] is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity and specific activity as specified. Identity, purity, and activity are confirmed via techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent composition is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as specified on the label and COA. For long-term storage, keep in a dedicated, properly shielded freezer. Users must handle this material in accordance with all local, national, and international regulations for radioactive substances.

Specification

Item	Specification
Appearance	Clear solution
Specific Activity	Customizable (e.g., 10-80 Ci/mmol)
Radiochemical Purity (RCP)	≥ 95% (by HPLC)
Chemical Purity (HPLC)	≥ 98%
Concentration	1 mCi/mL (or as customized)
Solvent	Ethanol, Ethanol:Water, or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.