Description

Cevimeline Sulfoxide is a key pharmaceutical intermediate and a significant metabolite of the active pharmaceutical ingredient Cevimeline. Its precise synthesis and high purity are critical for ensuring the quality, safety, and efficacy of downstream drug products. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical industry for analytical method development, metabolic studies, and the production of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Cevimeline hydrochloride and related cholinergic agents.
• Metabolite Reference Standard: Used in bioanalytical laboratories for pharmacokinetic and metabolic studies to understand drug behavior in the body.
• Analytical Research: Serves as a high-purity standard for method development and validation in quality control (QC) and research & development (R&D) settings.
• Process Impurity Profiling: Employed to identify, quantify, and control sulfoxide-related impurities during API manufacturing to meet stringent regulatory guidelines (e.g., ICH Q3A/B).
• Chemical Synthesis Research: Used as a model compound in organic chemistry research focusing on oxidation reactions and sulfur chemistry.

Basic Information

Product Name	Cevimeline Sulfoxide
CAS No.	124751-36-6
Molecular Formula	C10H17NOS2
Molecular Weight	231.38 g/mol
Synonyms	trans-2-Methylspiro(1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane) 1'-oxide; Cevimeline sulfoxide; Cevimeline S-oxide; (2R,3R)-2-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] 1'-oxide; AF102B sulfoxide; SNI-2011 sulfoxide; UNII-3P5Q6QY8QJ
EINECS	Contact for details

Quality Control

Our Cevimeline Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets exacting standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.