Description

5S-12R-Dihydroxy-6Z,8E,10E,14Z-Eicosatetraenoic-6,7,14,15-D4 Acid is a deuterium-labeled analog of the specialized pro-resolving mediator (SPM) Lipoxin A4. This compound is a critical research tool for studying the biochemical pathways and anti-inflammatory mechanisms of lipoxins in vivo and in vitro. It is essential for scientists in pharmaceutical R&D, biochemistry, and metabolic research who require precise, stable-isotope labeled standards for mass spectrometry, pharmacokinetic studies, and pathway elucidation.

Application

• Biochemical Research Standard: Used as an internal standard for the quantitative analysis of endogenous Lipoxin A4 via LC-MS/MS.
• Metabolic Pathway Tracing: Employed in tracer studies to investigate the biosynthesis, metabolism, and distribution of lipoxins.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing novel anti-inflammatory therapeutics targeting lipoxin pathways.
• Inflammation & Immunology Studies: Applied in cellular and animal models to dissect the precise role of Lipoxin A4 in the resolution of inflammation.
• Stable Isotope Labeling: The deuterium (D4) label provides a mass shift for accurate detection and minimizes interference from endogenous compounds.

Basic Information

Item	Detail
Product Name	5S-12R-Dihydroxy-6Z,8E,10E,14Z-Eicosatetraenoic-6,7,14,15-D4 Acid
CAS No.	124629-74-9
Molecular Formula	C20H28D4O4
Molecular Weight	340.48 g/mol (approx.)
Synonyms	Lipoxin A4-d4; LXA4-d4; 5S,12R-DiHETE-d4; (5S,6R,15S)-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic Acid-d4; 5S,12R-Dihydroxy-6,8,10,14-eicosatetraenoic-6,7,14,15-d4 Acid; Deuterated Lipoxin A4; [6,7,14,15-2H4]-LXA4
EINECS	Contact for details

Quality Control

Every batch of 5S-12R-Dihydroxy-6Z,8E,10E,14Z-Eicosatetraenoic-6,7,14,15-D4 Acid is produced and analyzed under strict quality protocols to ensure the highest standards of isotopic purity, chemical purity, and structural integrity. Our products undergo rigorous quality testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment (MS)	≥ 98 atom % D
Solubility	Soluble in ethanol, DMSO, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.