Description

Cevimeline CAS NO 124620-88-8 is a selective muscarinic acetylcholine receptor agonist, primarily targeting the M1 and M3 subtypes. This pharmacological profile makes it a critical active pharmaceutical ingredient (API) for addressing conditions related to exocrine gland secretion. It is essential for pharmaceutical manufacturers developing therapies for dry mouth (xerostomia), particularly in patients with Sjögren's syndrome. Our high-purity Cevimeline is supplied to meet the stringent demands of global pharmaceutical R&D and production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of xerostomia.
• Sjögren's Syndrome Therapy: Formulation into tablets or capsules specifically designed for managing symptoms of this autoimmune disorder.
• Research Chemical: Used in preclinical and clinical studies investigating muscarinic receptor function and new therapeutic applications.
• Drug Development: Serves as a reference standard and key intermediate in the synthesis of novel cholinergic agents.
• Specialty Formulations: Potential use in controlled-release or other advanced drug delivery systems to optimize pharmacokinetics.

Basic Information

Product Name	Cevimeline
CAS No.	124620-88-8
Molecular Formula	C10H17N3S
Molecular Weight	203.33 g/mol
Synonyms	AF102B; SNI-2011; Cevimeline Hydrochloride (salt form); (2R,3R)-2-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one; (αR,3R)-α-Methyl-1-azabicyclo[2.2.2]octane-3-acetonitrile; cis-2-Methylspiro(1,3-oxazolidine-5,3')quinuclidine; Evoxac (brand name)
EINECS	Contact for details

Quality Control

Our Cevimeline is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with typical purity levels exceeding 98.5% (HPLC). We provide comprehensive Certificates of Analysis (COA) that detail identity, purity, and impurity profiles. Our quality commitment aligns with ICH Q7 guidelines and supports regulatory filings for API registration.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.