Description

9-Norketo Fk-506 is a key pharmaceutical intermediate and a derivative of the potent immunosuppressant Tacrolimus (FK506). This compound is of significant interest in the research and development of novel immunosuppressive agents and for the synthesis of related metabolites. It serves as a critical building block for medicinal chemists and researchers in the pharmaceutical and biotechnology sectors, enabling the exploration of new therapeutic pathways and the production of high-purity reference standards.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of Tacrolimus (FK506) analogs and metabolites for immunosuppressive drug development.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to develop new immunomodulatory compounds with potentially improved efficacy or safety profiles.
• Biochemical Research: Employed in studies investigating the mechanism of action of calcineurin inhibitors and their interactions within biological systems.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled synthesis of specialized APIs for clinical trial materials or niche therapeutic applications.

Basic Information

Product Name	9-Norketo Fk-506
CAS No.	123719-19-7
Molecular Formula	C₄₃H₆₉NO₁₂
Molecular Weight	804.00 g/mol
Synonyms	9-Norketo Tacrolimus; 9-Norketo-FK506; 9-Nor-keto-FK 506; 23-O-Demethyl-9-oxo Tacrolimus; 23-O-Demethyl-9-oxo-FK506; 9-Oxo-23-O-demethyl Tacrolimus; 9-Oxo-23-O-demethyl-FK506; 9-Norketo FK-506
EINECS	Contact for details

Quality Control

Our 9-Norketo Fk-506 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.