Description

Rivastigmine is a potent and selective acetylcholinesterase inhibitor, a key active pharmaceutical ingredient (API) in the treatment of neurodegenerative disorders. Its primary commercial value lies in its proven efficacy for managing symptoms associated with Alzheimer's and Parkinson's disease dementia, offering significant therapeutic benefits. This high-purity compound is essential for pharmaceutical manufacturers engaged in the development and production of neurological medications, including transdermal patches and oral formulations, targeting a critical global healthcare need.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for Alzheimer's disease.
• Neurological Therapeutics: Formulation into capsules, oral solutions, and transdermal patches for Parkinson's disease dementia.
• Cognitive Disorder Research: A critical reference standard and tool in preclinical and clinical research for studying cholinergic pathways.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded rivastigmine products.
• Dosage Form Development: Used in R&D for developing novel delivery systems to improve patient compliance and efficacy.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for finished dosage form production.

Basic Information

Product Name	Rivastigmine
CAS No.	123441-03-2
Molecular Formula	C14H22N2O2
Molecular Weight	250.34 g/mol
Synonyms	(S)-3-[1-(Dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate; Exelon; SDZ ENA 713; ENA-713; Rivastigmine Hydrogen Tartrate (salt form); Rivastigmin; Rivastigmina; Rivastigminum; UNII-70D5FBB394
EINECS	Contact for details

Quality Control

Our Rivastigmine is manufactured under strict quality management systems to meet the rigorous standards of the global pharmaceutical industry. Each batch is tested to ensure compliance with relevant pharmacopoeial specifications (e.g., USP, EP) for identity, purity, and potency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature of 15-25°C (59-77°F) to minimize oxidation and ensure long-term stability. The container should be kept in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	-2.0° to +2.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.