Description

3'-Deoxy-2',3'-Didehydro-2'Fluorothymidine is a fluorinated nucleoside analog with significant research and pharmaceutical development potential. This compound is valued for its role as a key intermediate and active pharmaceutical ingredient (API) in the synthesis of novel antiviral and anticancer therapeutics. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in advanced drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation antiviral and antiretroviral drugs.
• Antiviral Research: Used in biochemical and virological studies to investigate mechanisms of action against viral polymerases.
• Oncology Research: Serves as a precursor or reference standard in the development of nucleoside-based chemotherapeutic agents.
• Biochemical Tool: Employed as a substrate or inhibitor in enzymatic assays to study DNA/RNA synthesis and repair pathways.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	3'-Deoxy-2',3'-Didehydro-2'Fluorothymidine
CAS No.	122757-54-4
Molecular Formula	C10H11FN2O4
Molecular Weight	242.20 g/mol
Synonyms	2'-Fluoro-2',3'-Didehydro-3'-deoxythymidine; 2'-F-ddT; 2'-Fluoro-2',3'-didehydro-3'-deoxythymidine; 2'-F-d4T; 2'-Fluoro-d4T; Alovudine (developmental name); 1-((2R,5S)-5-(Fluoromethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-2',3'-Didehydro-2'Fluorothymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.