Description

2',3'-Dideoxy-2',3'-Didehydro-2'-Fluorocytidine is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics. The compound, identified by CAS No. 122757-53-3, is handled under controlled conditions to maintain its integrity for sensitive applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of experimental antiviral and antineoplastic drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving reverse transcriptase or DNA/RNA polymerases.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside analogs.
• Antiviral Drug Development: Investigated for potential activity against a range of viruses, including HIV, HBV, and HCV.
• Academic Research: Utilized in university and institutional labs for fundamental studies on nucleotide metabolism and drug mechanisms.

Basic Information

Product Name	2',3'-Dideoxy-2',3'-Didehydro-2'-Fluorocytidine
CAS No.	122757-53-3
Molecular Formula	C9H10FN3O3
Molecular Weight	227.19 g/mol
Synonyms	2'-F-ddC; 2'-Fluoro-2',3'-dideoxy-2',3'-didehydrocytidine; 2'-F-d4C; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-4-amino-2(1H)-pyrimidinone; 4-Amino-1-((2R,4S,5R)-4-fluoro-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidin-2(1H)-one; 2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine; Fluorodidehydrodideoxycytidine
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-2',3'-Didehydro-2'-Fluorocytidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles to ensure compliance with research and development requirements. Specifications can be aligned with customer-specific needs for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.