Description

1-Pyrrolidinecarboxamide,4-(Dicyclohexylphosphino)-2-[(Diphenylphosphino)Methyl]-n-Methyl-,(2R,4R)- is a high-value, chiral phosphine ligand designed for advanced catalytic applications. This compound matters because it provides exceptional stereoselectivity and activity in asymmetric synthesis, enabling the production of high-purity enantiomerically enriched intermediates. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel synthetic routes and optimizing manufacturing processes for active ingredients.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig aminations for C-C and C-N bond formation.
• Hydroformylation Processes: Used to achieve high regioselectivity and enantioselectivity in the conversion of alkenes to chiral aldehydes.
• Academic and Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research.
• Scale-up and Process Chemistry: Facilitates the transition from laboratory-scale discovery to robust, cost-effective commercial manufacturing of chiral molecules.

Basic Information

Product Name	1-Pyrrolidinecarboxamide,4-(Dicyclohexylphosphino)-2-[(Diphenylphosphino)Methyl]-n-Methyl-,(2R,4R)-
CAS No.	122709-72-2
Molecular Formula	C31H43N2OP2
Molecular Weight	521.63 g/mol
Synonyms	(2R,4R)-4-(Dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]-N-methyl-2-pyrrolidinecarboxamide; (R,R)-DCPM; (2R,4R)-DCPM Ligand; (2R,4R)-N-Methyl-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine-2-carboxamide; (2R,4R)-Methyl-DCPM; Chiral DCPM Phosphine Ligand; (R,R)-N-Methyl-2-[(diphenylphosphino)methyl]-4-(dicyclohexylphosphino)pyrrolidine-1-carboxamide
EINECS	Contact for details

Quality Control

Our high-purity chiral ligands are manufactured under strict quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR (¹H, ³¹P, ¹³C), and chiral analysis to confirm identity, enantiomeric excess, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.