Description

4-Amino-1-(2-Deoxy-2,2-Difluoro-A-D-Erythro-Pentofuranosyl)-2(1H)-Pyrimidinone Hydrochloride is a high-purity nucleoside analog intermediate essential for pharmaceutical synthesis. This compound is critical for the production of advanced antiviral and anticancer therapeutics, where precise molecular structure and purity directly impact drug efficacy and safety. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel nucleoside-based active pharmaceutical ingredients (APIs).

Application

• Key Intermediate for Antiviral Drugs: Serves as a critical building block in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oncology Research & API Synthesis: Used in the development and manufacturing of chemotherapeutic agents that target DNA replication in cancer cells.
• Pharmaceutical R&D: Employed in medicinal chemistry for the discovery and optimization of new therapeutic nucleoside analogs.
• Process Development & Scale-Up: Utilized by CDMOs for process optimization, pilot-scale, and commercial-scale GMP manufacturing of APIs.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.
• Biochemical Research: Applied in academic and industrial research to study enzyme mechanisms, such as polymerase inhibition.

Basic Information

Product Name	4-Amino-1-(2-Deoxy-2,2-Difluoro-A-D-Erythro-Pentofuranosyl)-2(1H)-Pyrimidinone Hydrochloride
CAS No.	122111-05-1
Molecular Formula	C9H12ClF2N3O4
Molecular Weight	287.66 g/mol
Synonyms	Gemcitabine Impurity F; Gemcitabine Related Compound F; 2'-Deoxy-2',2'-difluorocytidine Hydrochloride; dFdC Hydrochloride; LY-188011 Hydrochloride; 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)cytosine Hydrochloride; 2'-Deoxy-2',2'-difluorocytidine HCl; 4-Amino-1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin-2(1H)-one Hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Amino-1-(2-Deoxy-2,2-Difluoro-A-D-Erythro-Pentofuranosyl)-2(1H)-Pyrimidinone Hydrochloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure it meets stringent specifications for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support regulatory compliance and supply chain transparency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.