Description

(R)-4-Vinyldihydrofuran-2(3H)-One is a high-value chiral lactone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a vinyl group adjacent to a stereogenic center, makes it a versatile precursor for constructing complex, optically active molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring specific stereochemistry for biological activity.
• Agrochemical Synthesis: Used in the research and development of novel, stereoselective pesticides and herbicides.
• Asymmetric Catalysis: Serves as a substrate or ligand precursor in the development of new catalytic systems for enantioselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is critical.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, including cycloaddition reactions and ring-opening polymerizations.

Basic Information

Product Name	(R)-4-Vinyldihydrofuran-2(3H)-One
CAS No.	121959-61-3
Molecular Formula	C6H8O2
Molecular Weight	112.13 g/mol
Synonyms	(R)-4-Vinylbutyrolactone; (R)-4-Vinyl-γ-butyrolactone; (R)-4-Vinyloxolan-2-one; (3R)-4-Ethenyldihydrofuran-2(3H)-one; (R)-4-Vinyl-γ-lactone; (R)-4-Vinylbutanolide; (R)-4-Vinyl-2-butyrolactone; (R)-γ-Vinyl-γ-butyrolactone
EINECS	Contact for details

Quality Control

Our (R)-4-Vinyldihydrofuran-2(3H)-One is produced under strict quality management protocols to ensure batch-to-batch consistency and high optical purity. Each lot is characterized by comprehensive analytical techniques including chiral HPLC, NMR, and GC to confirm identity, enantiomeric excess (ee), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.