Description

Tris(4-Methoxy-3,5-Dimethylphenyl)Phosphine is a specialized organophosphorus ligand with significant utility in advanced chemical synthesis. Its value lies in its ability to act as a highly effective ligand in transition metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig amination, enabling the production of complex pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over catalytic activity and selectivity. The product is supplied with a CAS number of 121898-64-4.

Application

• As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi) for C-C and C-N bond formation.
• Catalyst component in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Used in the development and manufacturing of agrochemicals and specialty fine chemicals.
• Facilitates polymerization catalysts for producing advanced polymeric materials.
• Employed in academic and industrial R&D for exploring new catalytic methodologies.
• Component in material science applications, such as OLED and electronic material precursors.

Basic Information

Product Name	Tris(4-Methoxy-3,5-Dimethylphenyl)Phosphine
CAS No.	121898-64-4
Molecular Formula	C27H33O3P
Molecular Weight	436.52 g/mol
Synonyms	Tris(2,6-Dimethyl-4-methoxyphenyl)phosphine; Phosphorous Tris(4-methoxy-3,5-dimethylphenyl) Ester; (4-Methoxy-3,5-dimethylphenyl)phosphine, tris-; Ligand SPhos (Note: SPhos is a closely related, common ligand; this is a specific analog); Tris(4-methoxy-3,5-dimethylphenyl)phosphane; Trixylylphosphine derivative; 4-Methoxy-3,5-dimethylphenylphosphine, tris-
EINECS	Contact for details

Quality Control

Every batch of Tris(4-Methoxy-3,5-Dimethylphenyl)Phosphine undergoes rigorous analytical testing to ensure high purity and consistency suitable for sensitive catalytic applications. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical and fine chemical GMP environments. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at room temperature (15-25°C). Due to its sensitivity to oxidation, prolonged exposure to air should be avoided. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.