Description

cis-(1S 2R)-U-50488 Tartrate Salt is a high-purity, enantiomerically pure chemical compound primarily utilized as a selective κ-opioid receptor (KOR) agonist in advanced pharmacological research. Its defined stereochemistry is critical for achieving specific receptor binding and activity, making it an essential tool for studying pain pathways, neuropsychiatric disorders, and substance abuse mechanisms. This compound is indispensable for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and neuropharmacology.

Application

• Pharmacological Research: A key reference standard and active agent for studying κ-opioid receptor (KOR) signaling and function in vitro and in vivo.
• Neuroscience & CNS Drug Discovery: Used to investigate the role of KOR in pain modulation, mood disorders, and addiction for novel therapeutic target validation.
• Biochemical Assay Development: Serves as a control compound in high-throughput screening (HTS) assays and receptor binding studies.
• Metabolic Pathway Studies: Employed in research to understand the metabolism and pharmacokinetics of selective opioid agonists.
• Academic Research: A vital reagent for university laboratories conducting fundamental research in neuropharmacology and medicinal chemistry.
• Preclinical Studies: Utilized in animal models to explore the physiological and behavioral effects of KOR activation.

Basic Information

Product Name	cis-(1S 2R)-U-50488 Tartrate Salt
CAS No.	121843-48-9
Molecular Formula	C20H28N2O8
Molecular Weight	424.45 g/mol
Synonyms	U-50488 Tartrate; (1S,2R)-U-50488 Tartrate; trans-(+/-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide Tartrate; U-50488H; U50488 Tartrate; U-50488 Hydrogentartrate; Kappa Opioid Receptor Agonist U-50488 Tartrate
EINECS	Contact for details

Quality Control

Our cis-(1S 2R)-U-50488 Tartrate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, assay, and impurity profile. We adhere to relevant quality guidelines for research chemicals to guarantee product integrity and reliable performance in sensitive experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.