Description

Cyclosporin A Sulfate is a chemically modified, water-soluble derivative of the potent immunosuppressive agent Cyclosporin A. This modification is critical for enhancing the compound's solubility profile, thereby expanding its utility in advanced pharmaceutical research and formulation development. It is primarily utilized by researchers and manufacturers in the fields of immunology, oncology, and drug delivery systems, where precise control over solubility and bioavailability is paramount.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the development of novel immunosuppressive therapies and drug delivery platforms.
• Solubility Enhancement Studies: Used to investigate and improve the aqueous solubility of Cyclosporin A for parenteral formulations.
• Cell Biology & Immunology: Employed in in vitro and ex vivo studies to modulate T-cell activation and cytokine production.
• Drug Delivery System Development: A candidate for incorporation into liposomes, nanoparticles, or other carrier systems to target specific tissues.
• Biochemical Reagent: Serves as a tool compound for studying calcineurin phosphatase inhibition and related intracellular signaling pathways.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	Cyclosporin A Sulfate
CAS No.	121673-00-5
Molecular Formula	C62H113N11O13 • H2SO4
Molecular Weight	1244.8 g/mol (for free base C62H113N11O13)
Synonyms	Cyclosporine A Sulfate; Ciclosporin A Sulfate; CsA Sulfate; Cyclosporin Sulfate; Sandimmune Sulfate; [R-[R*,R*-(E)]]-Cyclosporin A Sulfate; Cyclosporin A, sulfate
EINECS	Contact for details

Quality Control

Our Cyclosporin A Sulfate is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.