Description

Cyclosporin J CAS NO 121604-28-2 is a cyclic undecapeptide belonging to the cyclosporin family of immunosuppressive and anti-inflammatory metabolites. This compound is of significant interest in pharmaceutical research and development due to its structural similarity to Cyclosporin A and its potential for modulating biological pathways. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector, particularly those focused on immunology, oncology, and novel therapeutic agent discovery.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control in drug discovery and manufacturing.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of cyclosporin derivatives and their interactions with cellular targets like cyclophilins.
• Drug Discovery Intermediate: Serves as a key building block or precursor in the synthetic pathways for developing novel immunosuppressive or anti-inflammatory agents.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic profiling research to understand the biotransformation pathways of cyclosporin-based therapeutics.
• Academic & Institutional Research: A vital tool for universities and research institutes conducting fundamental research in immunology and molecular biology.
• Contract Research Organization (CRO) Services: Supplied to CROs for client-sponsored research projects requiring specific cyclosporin analogs.

Basic Information

Product Name	Cyclosporin J
CAS No.	121604-28-2
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin J; [Thr2,Leu5, D-Hiv8, Leu10]-Cyclosporin A; Cyclosporine J; UNII-1W3M6T3Z8U; 1W3M6T3Z8U; [Threonine-2,Leucine-5,(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoic Acid-8,Leucine-10]-Cyclosporin A; L-Threonine, N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-L-α-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-
EINECS	Contact for details

Quality Control

Our Cyclosporin J is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.