Description

1-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside analog, a critical building block in advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of novel antiviral and anticancer agents, where precise molecular structure is paramount. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of modified nucleoside analogs for antiviral and anticancer drug discovery programs.
• Antiviral Research: Used in the development of potential therapeutic agents targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a building block for creating nucleoside-based prodrugs and targeted cancer therapies.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleic acid metabolism and related pathways.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	121353-89-7
Molecular Formula	C10H13FN2O4
Molecular Weight	244.22 g/mol
Synonyms	5-Methyl-2'-fluoro-2',3'-dideoxyuridine; 2'-Fluoro-5-methyl-2',3'-dideoxyuridine; FddThd; 1-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-5-methyluracil; 2'-F-5-Me-ddU; 5-Methyl-1-(2-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)uracil
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-2,3-Dideoxy-β-D-Threo-Pentofuranosyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.