Description

D-[Ul-13C6]Glucitol is a stable isotope-labeled analog of D-glucitol (sorbitol), where all six carbon atoms are uniformly enriched with the carbon-13 (13C) isotope. This high-purity labeled compound is essential for advanced quantitative analysis and metabolic pathway tracing in research and development. It is primarily utilized by scientists and quality control professionals in the pharmaceutical, biotechnology, and nutritional science industries for applications requiring precise internal standards in mass spectrometry and NMR spectroscopy. The product is supplied with guaranteed isotopic enrichment and chemical purity to ensure reliable and reproducible experimental results.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Used as a certified reference material for the accurate quantification of D-glucitol and related metabolites in complex biological matrices like plasma, urine, and cell lysates.
• Metabolic Flux Analysis (MFA): Enables the tracing of carbon atoms through metabolic pathways, such as the polyol pathway, to study carbohydrate metabolism in diabetes research, cancer metabolism, and microbial fermentation.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a 13C-enriched tracer for structural elucidation and dynamic studies of metabolic processes, providing high-sensitivity detection.
• Pharmaceutical Drug Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the metabolism of drug candidates and excipients containing sugar alcohol moieties.
• Clinical Diagnostics Research: Facilitates the development of high-precision diagnostic assays for metabolic disorders (e.g., diabetes mellitus) by providing a stable isotope-labeled calibrant.
• Nutritional Science & Food Analysis: Used in research to investigate the absorption, distribution, and metabolism of sugar alcohols in nutritional studies and to ensure accurate food labeling.
• Biochemical Research Reagent: Acts as a critical tool in enzymology studies for enzymes like aldose reductase and sorbitol dehydrogenase.

Basic Information

Product Name	D-[Ul-13C6]Glucitol
CAS No.	121067-66-1
Molecular Formula	13C6H14O6
Molecular Weight	188.12 (for 13C6)
Synonyms	D-[U-13C6]Sorbitol; [13C6]-D-Glucitol; [U-13C6]-Sorbitol; (2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexaol-13C6; 13C6-Labeled D-Sorbitol; Isotope-labeled Sorbitol; 13C Uniformly Labeled Glucitol
EINECS	Contact for details

Quality Control

Every batch of D-[Ul-13C6]Glucitol is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, with specifications typically exceeding 98% chemical purity and 99% atom % 13C. Identity, purity, and isotopic abundance are confirmed by a combination of advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. Our quality commitment ensures the material is suitable for demanding applications in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.