Description

N(2),3-Ethenodeoxyguanosine is a modified nucleoside derivative, specifically an etheno adduct of deoxyguanosine. This compound is of significant interest in biochemical and toxicological research as a marker for DNA damage caused by exposure to certain carcinogens, such as vinyl chloride. It serves as a critical reference standard and reagent for scientists and quality control laboratories in the pharmaceutical, academic, and contract research sectors focused on genetic toxicology, biomarker discovery, and DNA repair studies.

Application

• Biomarker Research: Used as a quantitative standard for the detection and measurement of etheno-DNA adducts in biological samples, which are indicators of oxidative stress and exposure to environmental toxins.
• Toxicology Studies: Essential reference material in studies investigating the genotoxic effects of industrial chemicals like vinyl chloride and urethane, aiding in risk assessment.
• Method Development & Validation: Serves as a critical calibrant in the development and validation of sensitive analytical methods, including LC-MS/MS and HPLC, for DNA adductomics.
• Cancer Research: Employed in research exploring the role of specific DNA lesions in mutagenesis and the initiation mechanisms of chemical carcinogenesis.
• Diagnostic Kit Manufacturing: Used as a key component in the production of diagnostic kits and assays designed to screen for DNA damage and repair capacity.
• Pharmaceutical QC: Acts as a system suitability standard in quality control laboratories for monitoring potential genotoxic impurities in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	N(2),3-Ethenodeoxyguanosine
CAS No.	121055-53-6
Molecular Formula	C12H13N5O4
Molecular Weight	291.26 g/mol
Synonyms	1,N2-Etheno-2'-deoxyguanosine; 1,N2-Etheno-dG; 1,N2-ε-dG; 3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,9-dihydro-9-oxoimidazo[1,2-a]purine; N2,3-Ethenoguanine deoxyriboside; ε-dG; Etheno-dG; DNA Adduct 1,N2-Ethenodeoxyguanosine
EINECS	Contact for details

Quality Control

Our N(2),3-Ethenodeoxyguanosine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.