Description

Cbz-(R)-2-Phenylglycinol CAS NO 120666-53-7 is a high-purity chiral building block and intermediate of significant importance in asymmetric synthesis. Its primary value lies in its role as a key precursor for the preparation of enantiomerically pure pharmaceuticals and fine chemicals, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production facilities specializing in peptide chemistry, chiral auxiliaries, and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Peptide Chemistry: Used as a protected amino alcohol derivative in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Chiral Auxiliary & Ligand Synthesis: Serves as a precursor for the development of chiral catalysts, ligands (e.g., for asymmetric hydrogenation), and auxiliaries used in stereoselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring high optical purity.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory synthesis in medicinal chemistry and process research laboratories.

Basic Information

Product Name	Cbz-(R)-2-Phenylglycinol
CAS No.	120666-53-7
Molecular Formula	C16H17NO3
Molecular Weight	271.31 g/mol
Synonyms	(R)-2-(((Benzyloxy)carbonyl)amino)-2-phenylethanol; (R)-N-Carbobenzoxy-2-phenylglycinol; (R)-N-Cbz-2-phenylglycinol; (R)-2-((((Benzyloxy)carbonyl)amino)(phenyl)methyl)ethanol; (R)-N-[(Benzyloxy)carbonyl]-2-phenylglycinol; (R)-Cbz-Phenylglycinol; (R)-2-(((Cbz)amino)-2-phenylethanol; Benzyl (R)-(2-hydroxy-1-phenylethyl)carbamate
EINECS	Contact for details

Quality Control

Our Cbz-(R)-2-Phenylglycinol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet the stringent requirements of pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.