Description

(+/-)-Vesamicol Hydrochloride CAS NO 120447-62-3 is a potent and selective vesicular acetylcholine transporter (VAChT) inhibitor, a key pharmacological tool for neuroscience research. Its primary value lies in its ability to modulate cholinergic neurotransmission, making it essential for studying synaptic function, vesicular transport mechanisms, and neurodegenerative conditions. This compound is critically needed by pharmaceutical R&D teams, academic neuroscientists, and diagnostic developers focused on Alzheimer's disease, myasthenia gravis, and other cholinergic system disorders.

Application

• Neuroscience Research: A fundamental tool for investigating the function and regulation of the vesicular acetylcholine transport system in both in vitro and in vivo models.
• Neuropharmacology Studies: Used to characterize cholinergic pathways, receptor interactions, and the effects of cholinergic depletion on cognitive and motor functions.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics targeting neurodegenerative diseases.
• Diagnostic Agent Development: Explored as a precursor or reference compound in the synthesis of radiolabeled tracers (e.g., [³H] or [¹¹C]Vesamicol analogs) for Positron Emission Tomography (PET) imaging of cholinergic terminals.
• Biochemical Assays: Employed in high-throughput screening (HTS) assays to identify new modulators of VAChT activity and for validating assay systems.
• Toxicology & Safety Pharmacology: Used to model cholinergic dysfunction and study the systemic effects of impaired acetylcholine storage and release.

Basic Information

Product Name	(+/-)-Vesamicol Hydrochloride
CAS No.	120447-62-3
Molecular Formula	C20H28ClNO
Molecular Weight	333.90 g/mol
Synonyms	trans-2-(4-Phenylpiperidino)cyclohexanol Hydrochloride; AH-5183; (±)-Vesamicol HCl; Racemic Vesamicol Hydrochloride; VAChT Inhibitor; trans-2-(4-Phenyl-1-piperidinyl)cyclohexanol Hydrochloride; L-689,660 (racemate); Cholinergic Vesicle Blocker
EINECS	Contact for details

Quality Control

Our (+/-)-Vesamicol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details (racemic mixture)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.