Description

(-)-Carbovir CAS NO 120443-30-3 is the biologically active enantiomer of carbovir, a potent nucleoside reverse transcriptase inhibitor (NRTI). This compound serves as a critical intermediate in the research and development of novel antiviral therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on antiviral drug discovery, particularly for HIV and related retroviruses.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced antiviral prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Research: Used as a reference standard and active compound in biochemical assays to study HIV-1 reverse transcriptase inhibition.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop next-generation NRTIs.
• Preclinical Development: Employed in the formulation and efficacy testing of new antiviral candidates in non-clinical studies.
• Academic Research: Utilized in university and institutional labs for virology and enzymology research projects.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(-)-Carbovir
CAS No.	120443-30-3
Molecular Formula	C9H12N6O3
Molecular Weight	252.23 g/mol
Synonyms	(-)-Carbovir; (1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol; Abacavir intermediate; Cyclopropylcarbovir; GW 1592; NSC 614846; (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (-)-9-[(1S,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]guanine
EINECS	Contact for details

Quality Control

Our (-)-Carbovir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.