Description

Cgs 21680 is a potent and selective adenosine A2A receptor antagonist, widely recognized in pharmacological research by its CAS number 120225-54-9. This compound is a critical tool for investigating adenosine receptor signaling pathways, which are implicated in a range of neurological and cardiovascular functions. It is essential for researchers and pharmaceutical developers in the fields of neuroscience, cardiology, and drug discovery, enabling the study of Parkinson's disease, inflammation, and ischemia-reperfusion injury.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of adenosine A2A receptors in Parkinson's disease, Huntington's disease, and other movement disorders.
• Cardiovascular Research: Used to investigate cardioprotective mechanisms and the effects of A2A receptor blockade on ischemia-reperfusion injury.
• Immunology & Inflammation Studies: Applied in research exploring the modulation of immune responses and anti-inflammatory pathways mediated by adenosine receptors.
• Drug Discovery & Development: Serves as a reference standard and lead compound in high-throughput screening and the development of novel A2A receptor-targeting therapeutics.
• Biochemical Assays: Utilized in in vitro binding and functional assays (e.g., cAMP accumulation) to characterize receptor activity and compound efficacy.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes conducting basic science on purinergic signaling.

Basic Information

Product Name	Cgs 21680
CAS No.	120225-54-9
Molecular Formula	C15H18N6O2
Molecular Weight	314.35 g/mol
Synonyms	2-[p-(2-Carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosine; CGS-21680; CGS 21680; 2-[[4-(2-Carboxyethyl)phenyl]ethylamino]-5'-N-ethylcarboxamidoadenosine; Adenosine, 2-[[4-(2-carboxyethyl)phenyl]ethylamino]-5'-(N-ethylcarboxamide)-; 2-[(4-(2-Carboxyethyl)phenyl)ethylamino]-5'-N-ethylcarboxamidoadenosine
EINECS	Contact for details

Quality Control

Our Cgs 21680 is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.