Description

Cholesteryl Oleate, [Oleate-1-14C] is a carbon-14 radiolabeled derivative of cholesteryl oleate, a key cholesteryl ester. This compound is essential for advanced metabolic and pharmacokinetic research, providing a precise tracer for studying lipid absorption, transport, and metabolism in biological systems. It is primarily used by researchers and scientists in pharmaceutical R&D, biochemistry, and metabolic disease studies who require high-specific-activity tracers for sensitive detection and quantification.

Application

• Tracer Studies in Lipid Metabolism: Used to investigate the absorption, distribution, and catabolism of cholesteryl esters in vivo and in vitro.
• Drug Development & Pharmacokinetics (PK/ADME): A critical tool for studying the bioavailability, tissue distribution, and elimination pathways of lipid-based drug formulations.
• Biochemical Pathway Analysis: Enables the tracing of specific metabolic pathways related to cholesterol esterification and hydrolysis.
• Atherosclerosis & Cardiovascular Disease Research: Facilitates studies on the role of cholesteryl esters in foam cell formation and plaque development.
• Enzyme Activity Assays: Serves as a substrate for assaying the activity of enzymes like lecithin-cholesterol acyltransferase (LCAT) and cholesterol esterase.
• Lipoprotein Metabolism Studies: Used to label lipoproteins (e.g., LDL, HDL) for research into their metabolism and interaction with cells.

Basic Information

Product Name	Cholesteryl Oleate, [Oleate-1-14C]
CAS No.	119259-98-2
Molecular Formula	C45H78O2 (¹⁴C labeled)
Molecular Weight	~ 651.1 g/mol (unlabeled)
Synonyms	Cholesteryl cis-9-Octadecenoate-1-¹⁴C; 5-Cholesten-3β-yl (9Z)-9-Octadecenoate-1-¹⁴C; Cholesterol Oleate-1-¹⁴C; [1-¹⁴C]Oleoyl Cholesterol Ester; (3β)-Cholest-5-en-3-yl (9Z)-9-Octadecenoate-1-¹⁴C; Oleic Acid-1-¹⁴C Cholesteryl Ester; CE 18:1-1-¹⁴C
EINECS	Contact for details

Quality Control

Every batch of Cholesteryl Oleate, [Oleate-1-14C] is produced and analyzed under strict quality systems to ensure high chemical and radiochemical purity, as well as specific activity consistency. Our quality commitment includes adherence to cGMP principles for research chemicals. Comprehensive Certificates of Analysis (COA) detailing purity, radiochemical identity, specific activity, and solvent composition are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize radiolysis and oxidation. For long-term storage, solutions are recommended. Follow all applicable local and international regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution or solid
Identification (HPLC, TLC)	Conforms to standard
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol)
Solvent	Toluene, Ethanol, or as specified
Concentration	0.1 mCi/mL or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.