Description

Chlorhexidine-Ring-Ul-14C Dihydrochloride CAS NO 118897-03-3 is a radiolabeled derivative of the widely used antiseptic agent chlorhexidine, specifically labeled with carbon-14 on the ring structure. This compound is critical for conducting advanced pharmacokinetic, metabolic, and environmental fate studies with high precision and traceability. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and chemical safety sectors requiring definitive analytical data.

Application

• Metabolic and Pharmacokinetic Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of chlorhexidine in biological systems.
• Drug Development Research: Facilitates the quantification of drug residues and the identification of metabolites during preclinical and clinical development stages.
• Environmental Fate Analysis: Enables tracking and quantification of chlorhexidine and its degradation products in environmental samples to assess ecological impact.
• Analytical Method Development: Serves as a critical reference standard for validating HPLC, LC-MS, and other chromatographic methods used in quality control.
• Mechanistic Biochemical Research: Employed in studies to elucidate the precise mechanism of action and binding sites of chlorhexidine at the molecular level.
• Dermal Penetration Studies: Used in research to measure the skin permeation of chlorhexidine from topical antiseptic formulations.

Basic Information

Product Name	Chlorhexidine-Ring-Ul-14C Dihydrochloride
CAS No.	118897-03-3
Molecular Formula	C22H30Cl2N10 • 2HCl (with 14C labeling)
Molecular Weight	~578.4 g/mol (unlabeled base)
Synonyms	1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide]-Ring-Ul-14C Dihydrochloride; Chlorhexidine dihydrochloride-14C; Chlorhexidine-14C Dihydrochloride; N,N''''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide-Ring-Ul-14C Dihydrochloride; [14C]-Chlorhexidine 2HCl; Radiolabeled Chlorhexidine Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of our Chlorhexidine-Ring-Ul-14C Dihydrochloride is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity and chemical purity, with comprehensive testing including HPLC, NMR, and mass spectrometry for identity and potency confirmation. Certificates of Analysis (COA) detailing specific activity, purity, and analytical results are provided with each shipment to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is strictly light-sensitive and hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere if the container is opened frequently.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Radiochemical Purity	≥ 97.0%
Specific Activity	Customizable, typically 50-60 mCi/mmol
Solubility	Soluble in water, DMSO, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.