Description

Chlorhexidine-Ring-Ul-14C Digluconate is a radiolabeled analog of the widely used antiseptic agent chlorhexidine digluconate, specifically labeled with carbon-14 on the chlorhexidine ring structure. This compound is essential for conducting advanced pharmacokinetic, metabolic, and environmental fate studies, providing critical data for regulatory submissions and research validation. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on antimicrobial agent development and safety assessment.

Application

• Tracer Studies in Antimicrobial Research: Used as a radioactive tracer to study the absorption, distribution, metabolism, and excretion (ADME) profile of chlorhexidine in preclinical models.
• Metabolic Pathway Elucidation: Critical for identifying and quantifying metabolites of chlorhexidine in biological systems to understand its biotransformation.
• Environmental Fate and Residue Analysis: Employed in studies to track the environmental persistence, degradation, and binding of chlorhexidine residues in various matrices.
• Dermal Penetration and Bioavailability Studies: Facilitates precise measurement of the compound's penetration through skin or mucous membranes in formulation testing.
• Mechanism of Action Research: Aids in investigating the specific binding sites and mechanisms of chlorhexidine's antimicrobial activity at a molecular level.
• Quality Control and Method Development: Serves as an internal standard or reference material in developing and validating sensitive analytical methods (e.g., LC-MS/MS) for chlorhexidine quantification.

Basic Information

Product Name	Chlorhexidine-Ring-Ul-14C Digluconate
CAS No.	118897-02-2
Molecular Formula	C34H54Cl2N10O14 * (14C labeled)
Molecular Weight	Contact for details
Synonyms	1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide]-Ring-Ul-14C Digluconate; Chlorhexidine Gluconate-14C; Chlorhexidine di-D-gluconate (14C-labeled); Chlorhexidine-14C Digluconate; [Ring-Ul-14C]-Chlorhexidine Digluconate; N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide-Ring-Ul-14C Digluconate
EINECS	Contact for details

Quality Control

Every batch of our Chlorhexidine-Ring-Ul-14C Digluconate is manufactured and analyzed under strict quality systems. The product is characterized to ensure high chemical and radiochemical purity, specific activity, and stability. Comprehensive analytical data, including Certificates of Analysis (COA) detailing radiochemical purity (by HPLC), specific activity, and chemical identification, are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product should be handled in accordance with all applicable radiation safety regulations and guidelines for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details (mCi/mmol)
Concentration	Customizable (typically provided in ethanol/water solution)
Solvent	Ethanol/Water or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.