Description

Dihydroxyphenylalanine, Dl-3,4-[Alanine-1-14C] is a radiolabeled analog of the amino acid L-DOPA, where the carbon at the 1-position of the alanine side chain is the carbon-14 isotope. This compound is a critical tool for metabolic and pharmacokinetic studies, enabling precise tracking and quantification in biological systems. It is primarily used by researchers and scientists in pharmaceutical development, neurochemistry, and biochemistry for tracer studies, drug metabolism and disposition (DMPK) research, and enzymatic pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of dopaminergic compounds and related pharmaceuticals.
• Biochemical Pathway Analysis: Employed in research to trace and elucidate biosynthetic and catabolic pathways involving dopamine and catecholamines in vitro and in vivo.
• Neurochemical Research: Serves as a precursor tracer for studying dopamine synthesis, storage, release, and reuptake mechanisms in neurological models.
• Analytical Method Development: Acts as an internal standard or reference compound in the development and validation of sensitive analytical methods, such as LC-MS/MS or radio-HPLC.
• Preclinical Research: Utilized in animal studies to model Parkinson's disease and other dopaminergic system disorders, providing critical data on compound biodistribution.

Basic Information

Product Name	Dihydroxyphenylalanine, Dl-3,4-[Alanine-1-14C]
CAS No.	118118-98-2
Molecular Formula	C9H11NO4 (with 14C label)
Molecular Weight	Contact for details
Synonyms	DL-3,4-Dihydroxyphenyl[1-14C]alanine; DL-[1-14C]DOPA; DL-β-(3,4-Dihydroxyphenyl)[1-14C]alanine; Racemic [1-14C]DOPA; 2-Amino-3-(3,4-dihydroxyphenyl)[1-14C]propanoic acid; DL-[1-14C]Dihydroxyphenylalanine; Carbon-14 labeled DL-DOPA
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and tested to meet the exacting standards required for research and development. Certificates of Analysis (COA) are provided, detailing critical parameters such as radiochemical purity, specific activity, chemical purity, and solvent composition. Our quality systems ensure traceability and consistency, supporting compliance with GLP (Good Laboratory Practice) standards for reliable research outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. The product should be kept in the original container in a designated, well-ventilated area for radioactive materials. Users must follow all applicable radiation safety guidelines and regulations for handling and storage.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, MS)	Conforms
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details (mCi/mmol)
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Specified on label and COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.