Description

D-Glucuronicacid-(6-C14) is a carbon-14 radiolabeled derivative of D-glucuronic acid, a key metabolic intermediate. This compound is essential for conducting precise metabolic and pharmacokinetic studies, providing critical data on drug metabolism, detoxification pathways, and biochemical synthesis. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical industries for advanced tracer studies.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to investigate Phase II metabolism, specifically glucuronidation pathways, for new chemical entities.
• Biochemical Pathway Analysis: Essential for tracing the metabolic fate of D-glucuronic acid in studies of glycosaminoglycan biosynthesis (e.g., hyaluronic acid, heparan sulfate).
• Toxicology and Detoxification Research: Employed to study the body's detoxification mechanisms, where substances are conjugated with glucuronic acid for excretion.
• Enzymology Studies: Serves as a substrate for enzymes like UDP-glucuronosyltransferases (UGTs) in enzyme activity and inhibition assays.
• Radiochemical Synthesis: Acts as a labeled building block for the synthesis of more complex radiolabeled carbohydrates or glycoconjugates.
• Environmental Fate Studies: Applied in research to track the biodegradation pathways of glucuronide-conjugated compounds in the environment.

Basic Information

Product Name	D-Glucuronicacid-(6-C14)
CAS No.	117608-68-1
Molecular Formula	C6H10O7 (with C-14 at position 6)
Molecular Weight	~196.14 g/mol (unlabeled)
Synonyms	(6-14C)-D-Glucuronic Acid; D-Glucuronic-6-14C Acid; Glucuronic Acid-6-14C; 6-Carbon-14-Labeled D-Glucuronic Acid; (6-14C)Glucuronic Acid; 6-14C-Glucuronate; 6-14C-GlcA; 117608-68-1
EINECS	Contact for details

Quality Control

Every batch of D-Glucuronicacid-(6-C14) is manufactured and tested to meet the stringent requirements for radiolabeled biochemicals. Our quality assurance includes verification of radiochemical purity and specific activity using advanced analytical techniques. A comprehensive Certificate of Analysis (COA), detailing purity, activity, and analytical methods (e.g., HPLC, radio-HPLC), is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere if specified. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to Off-White Solid
Identification (IR)	Conforms to Structure
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.