Description

2',3'-Dideoxyuridine 5'-Monophosphate is a chemically modified nucleoside monophosphate, a critical building block in nucleic acid research and therapeutic development. This compound is essential for studying viral replication mechanisms and developing novel antiviral agents, particularly against retroviruses. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on virology and molecular biology.

Application

• Antiviral Research: Serves as a key intermediate in the synthesis and study of nucleoside analog prodrugs targeting viral polymerases.
• Biochemical Substrate: Used as a specific substrate or inhibitor in enzymatic assays to study kinase and phosphorylase activity.
• Probe Development: Acts as a precursor for labeled compounds (e.g., fluorescent or radioactive probes) used in molecular diagnostics and imaging.
• Nucleic Acid Chemistry: Employed in oligonucleotide synthesis to incorporate modified bases, enabling the study of DNA/RNA structure and function.
• Mechanistic Studies: Facilitates research into chain termination mechanisms and DNA replication fidelity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical development.

Basic Information

Product Name	2',3'-Dideoxyuridine 5'-Monophosphate
CAS No.	117605-34-2
Molecular Formula	C9H13N2O8P
Molecular Weight	308.18 g/mol
Synonyms	2',3'-Dideoxyuridine 5'-monophosphate; ddUMP; 2',3'-Dideoxyuridylic acid; 5'-Monophosphate of 2',3'-dideoxyuridine; Uridine, 2',3'-dideoxy-, 5'-(dihydrogen phosphate); 2',3'-ddUMP; 5'-O-Phosphono-2',3'-dideoxyuridine; NSC 614391
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyuridine 5'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Under these conditions, the product is stable for at least 24 months. The compound is hygroscopic; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.