Description

2,5-Difluoro-4-Nitrobenzoic Acid is a versatile fluorinated aromatic building block characterized by its benzoic acid core substituted with nitro and fluorine groups. This compound matters as a critical intermediate in advanced organic synthesis, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that benefit from fluorinated structures for enhanced activity and stability.
• Material Science Research: Serves as a precursor for functionalized monomers or ligands in the development of specialty polymers and advanced materials.
• Organic Synthesis Reagent: Employed in coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to introduce the difluoro-nitrobenzoic acid moiety into more complex molecules.
• Liquid Crystal & OLED Material Development: Acts as a starting material for synthesizing fluorinated aromatic components used in electronic displays and optoelectronic devices.
• Chemical Biology & Proteomics: Useful for creating chemical probes or affinity tags due to its reactive carboxylic acid and nitro groups.

Basic Information

Product Name	2,5-Difluoro-4-Nitrobenzoic Acid
CAS No.	116465-48-6
Molecular Formula	C7H3F2NO4
Molecular Weight	203.10 g/mol
Synonyms	4-Nitro-2,5-difluorobenzoic Acid; Benzoic acid, 2,5-difluoro-4-nitro-; 2,5-Difluoro-4-nitro-benzoic acid; 2,5-Difluoro-4-nitrobenzoic acid; 116465-48-6; 4-Nitro-2,5-difluorobenzoic acid; Difluoronitrobenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-Nitrobenzoic Acid is produced and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.