Description

L-Tryptophan (Indole-2-13C) is a stable isotope-labeled analog of the essential amino acid L-Tryptophan, where the carbon atom at the 2-position of the indole ring is enriched with the 13C isotope. This compound is a critical tool for advanced research, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug metabolism studies, proteomics, and clinical diagnostics.

Application

• Isotope-Labeled Internal Standards: For accurate quantification of L-Tryptophan and related metabolites in biological samples using mass spectrometry (LC-MS/MS, GC-MS).
• Metabolic Flux Analysis (MFA): As a tracer to study the dynamics of tryptophan metabolism in cell cultures, tissues, or whole organisms.
• Pharmaceutical Research & Development: In drug discovery and development for investigating the pharmacokinetics, bioavailability, and metabolic fate of new chemical entities.
• Clinical Diagnostics & Biomarker Discovery: To develop sensitive and specific assays for detecting metabolic disorders related to tryptophan pathways.
• Nutritional Science Research: For studying protein synthesis, amino acid uptake, and metabolic regulation in nutritional studies.
• Proteomics & Protein Labeling: Used in metabolic labeling strategies (e.g., SILAC) for comparative protein expression analysis.

Basic Information

Product Name	L-Tryptophan (Indole-2-13C)
CAS No.	115709-68-7
Molecular Formula	C10H12N2O2 (with 13C at Indole-2)
Molecular Weight	~205.22 g/mol (13C labeled)
Synonyms	(S)-2-Amino-3-(1H-indol-3-yl)propanoic-2-13C; Tryptophan-2-13C; L-Tryptophan-2-13C; L-TRP-2-13C; (2S)-2-Amino-3-(1H-indol-3-yl)propanoic acid (indole-2-13C); 13C Labeled L-Tryptophan; Tryptophan (indole ring-2-13C); Stable Isotope Labeled Tryptophan
EINECS	Contact for details

Quality Control

Our L-Tryptophan (Indole-2-13C) is manufactured under strict quality systems to ensure the highest standards of isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity (by HPLC), chiral purity, and residual solvent content. We support research and regulatory needs with documentation suitable for cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (13C labeled)
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Optical Rotation	[α]20/D: -30.0° to -34.0° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.