Description

n-[((2S)-1-Ethyl-2-Pyrrolidinyl)Methyl]-5-(125I)Iodo-2-Methoxybenzamide is a specialized iodinated radiopharmaceutical compound designed for research and diagnostic applications. This compound is critical for studies in neuroscience and pharmacology, particularly in the non-invasive imaging and quantification of specific receptor systems in the brain. It is primarily utilized by research institutions, pharmaceutical developers, and clinical diagnostic centers engaged in positron emission tomography (PET) imaging.

Application

• PET Imaging Tracer: Used as a radioligand for in vivo imaging and quantification of dopamine D2/D3 receptors in the brain.
• Neuropharmacology Research: Enables the study of receptor occupancy, binding affinity, and the effects of novel therapeutic agents on the central nervous system.
• Neurological Disorder Studies: Applied in research models for conditions such as Parkinson's disease, schizophrenia, and substance abuse disorders.
• Drug Development: Serves as a key tool in the preclinical and clinical evaluation of new antipsychotic and neurologic drugs.
• Metabolic Pathway Investigation: Assists in tracing and understanding biochemical pathways related to dopaminergic signaling.

Basic Information

Product Name	n-[((2S)-1-Ethyl-2-Pyrrolidinyl)Methyl]-5-(125I)Iodo-2-Methoxybenzamide
CAS No.	115655-33-9
Molecular Formula	C15H22IN2O2 *
Molecular Weight	428.26 g/mol *
Synonyms	IBZM (Iodobenzamide); (S)-(-)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide; (S)-IBZM; Raclopride analog; Dopamine D2 receptor ligand [125I]; 5-Iodo-2-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide; (S)-(-)-5-Iodo-2-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide
EINECS	Contact for details

* Calculated for the non-radioactive iodine-127 analog. The exact molecular weight for the 125I-labeled compound is subject to the specific activity of the radiolabeled batch.

Quality Control

Every batch of this high-purity radiochemical is manufactured and tested under strict cGMP-like conditions to ensure consistency and reliability for critical research. Quality assurance includes rigorous analysis for radiochemical purity (>95%) and specific activity via validated methods such as radio-HPLC and gamma counting. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, solvent content, and analytical chromatograms is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its radioactive nature and sensitivity, store at or below -20°C. The product should be stored in appropriate shielded containers in a designated radioactive materials area. Use appropriate safety precautions and adhere to all local and international regulations for handling radioactive substances.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (Radiometric HPLC)	≥ 95%
Specific Activity	≥ 2000 Ci/mmol (74 TBq/mmol) at reference date
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol (specified concentration)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.