Description

L-Glutamic-3-13C Acid is a stable isotope-labeled analog of the essential amino acid L-glutamic acid, where the carbon atom at the 3-position is enriched with the 13C isotope. This compound is a critical tool for advanced metabolic research, enabling precise tracking and quantification of glutamic acid pathways in biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutritional science industries for applications in tracer studies, mass spectrometry, and NMR spectroscopy.

Application

• Metabolic Tracer Studies: Used in in vitro and in vivo research to elucidate glutamic acid metabolism, neurotransmitter cycling, and energy pathways.
• Quantitative Mass Spectrometry (MS): Serves as an internal standard for the accurate quantification of endogenous glutamic acid levels in complex biological matrices like plasma, urine, and tissue homogenates.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Employed in structural and dynamic studies of metabolic processes due to the distinct NMR signal of the 13C label.
• Drug Discovery & Development: Facilitates pharmacokinetic and pharmacodynamic studies to understand drug metabolism and mechanism of action.
• Nutritional Research: Used to study amino acid absorption, protein synthesis, and metabolic flux in nutritional and clinical studies.
• Biochemical Reagent Manufacturing: Incorporated into high-precision diagnostic kits and research assay components.

Basic Information

Product Name	L-Glutamic-3-13C Acid
CAS No.	115473-51-3
Molecular Formula	C413CH9NO4
Molecular Weight	148.11 g/mol (for 13C labeled form)
Synonyms	(2S)-2-Aminopentanedioic-3-13C Acid; L-Glutamic Acid-3-13C; (S)-2-Aminopentanedioic-3-13C Acid; Glutamic Acid-3-13C; L-Glu-3-13C; 13C Labeled L-Glutamic Acid; 3-13C-L-Glutamic Acid; Stable Isotope-Labeled Glutamic Acid
EINECS	Contact for details

Quality Control

Every batch of L-Glutamic-3-13C Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. A Certificate of Analysis (COA) detailing specifications such as isotopic purity (atom % 13C), chemical purity (by HPLC), chiral purity, and residual solvent content is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (Atom % 13C)	≥ 99%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.