Description

Dichloroimipramine Hydrochloride is a high-purity pharmaceutical intermediate and research chemical with the CAS registry number 115189-28-1. This compound is of significant value in the development and synthesis of novel active pharmaceutical ingredients (APIs) and for advanced pharmacological research. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the production of specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of tricyclic antidepressant analogs and related central nervous system (CNS) active compounds.
• Research & Development: Used as a reference standard and precursor in medicinal chemistry for structure-activity relationship (SAR) studies.
• Biochemical Research: Employed in pharmacological assays to study neurotransmitter reuptake inhibition mechanisms.
• Fine Chemical Synthesis: Serves as a specialized reagent for creating novel chemical entities in contract research and manufacturing organizations (CROs/CMOs).
• Analytical Standard: Utilized in quality control laboratories for method development and validation in HPLC and LC-MS analyses.

Basic Information

Product Name	Dichloroimipramine Hydrochloride
CAS No.	115189-28-1
Molecular Formula	C20H25Cl2N2•HCl
Molecular Weight	397.80 g/mol (Hydrochloride salt)
Synonyms	3-(3-(Dimethylamino)propyl)-10,11-dichloro-5H-dibenzo[b,f]azepine hydrochloride; 10,11-Dichloroimipramine hydrochloride; NSC 339024; 5H-Dibenzo[b,f]azepine-5-propanamine, 10,11-dichloro-N,N-dimethyl-, hydrochloride; Imipramine, 10,11-dichloro-, hydrochloride; Dichlorodesipramine hydrochloride (related isomer)
EINECS	Contact for details

Quality Control

Our Dichloroimipramine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.