Description

20-Trifluoro Leukotriene B4 is a fluorinated analog of the potent inflammatory mediator Leukotriene B4, designed to enhance metabolic stability and receptor binding specificity for advanced research applications. This compound is critical for investigating the role of leukotrienes in inflammatory pathways, offering researchers a more stable tool for in vitro and in vivo studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel anti-inflammatory therapeutics and understanding immune system signaling.

Application

• Biochemical Research: Used as a stable, fluorinated probe to study leukotriene receptor (BLT1/BLT2) binding, activation, and downstream signaling cascades in inflammatory models.
• Pharmaceutical Development: Serves as a key reference standard and intermediate in the discovery and development of new anti-inflammatory drugs targeting the 5-lipoxygenase pathway.
• Metabolic Studies: Employed to investigate the metabolic fate and stability of leukotriene analogs, providing insights into drug design for improved pharmacokinetics.
• Cell Biology & Immunology: Applied in cell-based assays to elucidate the role of Leukotriene B4 in neutrophil chemotaxis, degranulation, and other immune cell functions.
• Analytical Standard: Used for method development, calibration, and quantification in analytical techniques such as HPLC and LC-MS for leukotriene analysis in biological samples.

Basic Information

Product Name	20-Trifluoro Leukotriene B4
CAS No.	115178-97-7
Molecular Formula	C₂₀H₂₉F₃O₄
Molecular Weight	390.44 g/mol
Synonyms	20,20,20-Trifluoroleukotriene B4; 20-Trifluoro-LTB4; 5(S),12(R)-Dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic Acid, 20,20,20-Trifluoro Derivative; 20-Trifluoro-5(S),12(R)-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid; 20-F3-LTB4; 20-Trifluoro LTB4; 20-F₃-LTB₄
EINECS	Contact for details

Quality Control

Our 20-Trifluoro Leukotriene B4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.