Description

2-Pyridinecarboxylic Acid, 5-Amino-, Labeled With Tritium (9Ci) is a high-specific-activity radiolabeled derivative of 5-aminopicolinic acid, a key intermediate in medicinal chemistry and biochemical research. This tritiated compound is essential for conducting advanced radioligand binding assays, metabolic pathway tracing, and autoradiography studies with high sensitivity and precision. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on drug discovery, receptor characterization, and pharmacokinetic analysis.

Application

• Drug Discovery & Development: As a radiolabeled tracer in preclinical studies for investigating the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities.
• Biochemical Research: For use in radioligand binding assays to study receptor-ligand interactions, enzyme kinetics, and target engagement.
• Metabolic Pathway Analysis: To trace and quantify metabolic products and pathways in biological systems using autoradiography or liquid scintillation counting.
• Pharmaceutical Impurity Profiling: As an internal standard or tracer in advanced analytical methods like LC-MS for quantifying trace-level metabolites or degradants.
• Chemical Synthesis Intermediate: Serving as a building block for the synthesis of more complex tritium-labeled molecules for specialized research applications.

Basic Information

Product Name	2-Pyridinecarboxylic Acid, 5-Amino-, Labeled With Tritium (9Ci)
CAS No.	114849-40-0
Molecular Formula	C₆H₄N₂O₂ (Tritium labeled)
Molecular Weight	~138.11 g/mol (unlabeled)
Synonyms	5-Aminopicolinic Acid, Tritium Labeled; [³H]-5-Aminopicolinic Acid; 5-Amino-2-pyridinecarboxylic Acid (Tritiated); 2-Carboxy-5-aminopyridine (³H); 5-Amino-2-picolinic Acid (Tritium Label); 5-Aminopyridine-2-carboxylic Acid (³H); Picolinic Acid, 5-Amino-, Tritiated
EINECS	Contact for details

Quality Control

Every batch of this radiolabeled compound is produced and tested under stringent conditions to ensure radiochemical purity, specific activity, and chemical identity. Quality assurance protocols include analysis by HPLC with radiometric detection and spectroscopic methods. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the specific activity (9Ci), radiochemical purity, and solvent composition. Our quality system is designed to meet the exacting standards required for GLP and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as specified on the label. For long-term storage, keep in a dedicated, properly shielded freezer designed for radioactive materials. Always handle and store in accordance with local and international regulations for radioactive substances.

Specification

Item	Specification
Appearance	Clear solution (color may vary)
Specific Activity	9 Ci/mmol (Nominal)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Identification (IR / NMR)	Conforms to structure
Solvent	Ethanol / Toluene or as specified
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.