Description

5-Tfa-Ap-2',3'-Dideoxycytidine is a chemically modified nucleoside analog, specifically a derivative of 2',3'-dideoxycytidine. This compound is a critical building block in advanced pharmaceutical research and development, particularly in the synthesis of nucleotide-based therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, prodrugs, and novel oligonucleotide sequences.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drugs.
• Antiviral Research: Used in biochemical studies to investigate mechanisms of viral replication and to screen for new therapeutic candidates against viruses such as HIV and HBV.
• Prodrug Synthesis: Acts as a scaffold for creating prodrug forms of nucleoside analogs, aiming to improve bioavailability and targeted delivery.
• Oligonucleotide Chemistry: Employed in the solid-phase synthesis of modified oligonucleotides for antisense, siRNA, or aptamer applications.
• Biochemical Tool: Functions as a substrate or inhibitor in enzymatic assays to study polymerase and kinase activity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	5-Tfa-Ap-2',3'-Dideoxycytidine
CAS No.	114748-58-2
Molecular Formula	C₁₄H₁₅F₃N₄O₅
Molecular Weight	376.29 g/mol
Synonyms	5-Trifluoroacetyl-2',3'-dideoxycytidine; 5-Trifluoroacetylamino-2',3'-dideoxycytidine; 5-(Trifluoroacetamido)-2',3'-dideoxycytidine; 5-TFA-2',3'-ddC; 5-Trifluoroacetylamino-2',3'-dideoxycytidine; 2',3'-Dideoxy-5-trifluoroacetamidocytidine; N-[4-Amino-2-(hydroxymethyl)-2,3-dihydro-5-pyrimidinyl]-2,2,2-trifluoroacetamide (related form)
EINECS	Contact for details

Quality Control

Our 5-Tfa-Ap-2',3'-Dideoxycytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.