Description

R-(-)-Fluoxetine Hydrochloride CAS NO 114247-09-5 is the single enantiomer form of the widely used selective serotonin reuptake inhibitor (SSRI). This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in neuropharmacology and chiral drug synthesis.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure fluoxetine and related SSRI APIs.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Building block for research into novel central nervous system (CNS) therapeutics and metabolite studies.
• Precursor for the preparation of deuterated or other isotopically labeled analogs for clinical research.
• Starting material for process chemistry research and scale-up optimization in API manufacturing.
• Critical reagent in pharmacological studies investigating the specific activity of the R-enantiomer.

Basic Information

Product Name	R-(-)-Fluoxetine Hydrochloride
CAS No.	114247-09-5
Molecular Formula	C17H19F3NO • HCl
Molecular Weight	345.79 g/mol (Free base: 309.33 g/mol)
Synonyms	(R)-(-)-Fluoxetine HCl; (R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride; (R)-Fluoxetine hydrochloride; R-Fluoxetine HCl; (R)-Prozac Hydrochloride; (R)-Lilly 110140 hydrochloride; (R)-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride
EINECS	Contact for details

Quality Control

Our R-(-)-Fluoxetine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and development purposes. A detailed Certificate of Analysis (COA) documenting identity, purity, enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.