Description

18-Carboxy-19,20-Dinor-n-Acetylleukotriene E4 is a specialized leukotriene analog and a key intermediate in the synthesis of bioactive lipid mediators. This compound is critical for research and development in inflammatory pathways and receptor studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on respiratory and immunological therapeutics.

Application

• Biochemical Research: Used as a reference standard and intermediate in the study of leukotriene biosynthesis and metabolism.
• Pharmaceutical Development: Serves as a key building block for synthesizing novel anti-inflammatory drug candidates targeting leukotriene receptors.
• In Vitro Assays: Employed in cell-based and enzymatic assays to investigate the role of leukotrienes in asthma, allergies, and other inflammatory conditions.
• Metabolite Analysis: Acts as a crucial analytical standard in LC-MS and HPLC methods for quantifying leukotriene metabolites in biological samples.
• Signal Transduction Studies: Utilized to probe and modulate cysteinyl leukotriene receptor (CysLT) activity and downstream signaling cascades.

Basic Information

Product Name	18-Carboxy-19,20-Dinor-n-Acetylleukotriene E4
CAS No.	114115-51-4
Molecular Formula	C25H39NO8S
Molecular Weight	513.65 g/mol
Synonyms	18-Carboxy-19,20-dinor-N-acetyl-LTE4; Dinor-N-acetyl-LTE4; 18-COOH-19,20-dinor-N-acetyl-LTE4; Leukotriene E4 metabolite analog; N-Acetyl-18-carboxy-19,20-dinorleukotriene E4; ω-Carboxy-dinor-N-acetyl-LTE4; LTE4 dinor metabolite
EINECS	Contact for details

Quality Control

Our 18-Carboxy-19,20-Dinor-n-Acetylleukotriene E4 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.