Description

Nicotinamide-(Amide-15N) is a stable isotope-labeled analog of nicotinamide, where the nitrogen atom in the amide group is the 15N isotope. This compound is essential as an internal standard and tracer in advanced mass spectrometry and NMR-based research, enabling precise quantification and metabolic pathway analysis. It is primarily used by researchers and manufacturers in the pharmaceutical, nutraceutical, and life science sectors for drug metabolism studies, biomarker discovery, and the development of high-purity labeled compounds.

Application

• Internal standard for the accurate quantification of nicotinamide and related metabolites in biological samples via LC-MS/MS.
• Tracer compound in metabolic flux analysis and pharmacokinetic studies to elucidate vitamin B3 pathways.
• Critical reagent in the synthesis of isotopically labeled NAD+, NADP+, and other coenzymes for biochemical research.
• Used in the development and validation of analytical methods for compliance testing in pharmaceutical quality control.
• Precursor for manufacturing high-purity, labeled reference materials and certified standards.
• Research tool in nutritional science to study niacin (Vitamin B3) absorption, distribution, and metabolism.

Basic Information

Product Name	Nicotinamide-(Amide-15N)
CAS No.	113950-01-9
Molecular Formula	C6H615N2O
Molecular Weight	123.11 g/mol (for 15N1)
Synonyms	Nicotinamide-amide-15N; 3-Pyridinecarboxamide-amide-15N; Niacinamide-amide-15N; Vitamin B3 (amide-15N); 15N-Nicotinamide; [amide-15N]-Nicotinamide; Nicotinic acid amide-amide-15N; Pyridine-3-carboxamide-amide-15N
EINECS	Contact for details

Quality Control

Our Nicotinamide-(Amide-15N) is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment (by MS), and related substance profiles. We adhere to cGMP principles for research chemical manufacture, ensuring traceability, consistency, and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of water vapor.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % 15N
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.