Description

Cyclic-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine is a chemically modified nucleotide analog with significant biological activity. This compound matters for its role as a key intermediate and active pharmaceutical ingredient (API) in the development of antiviral and anticancer therapeutics. Pharmaceutical manufacturers, biotechnology research institutions, and fine chemical suppliers need it for advanced drug synthesis and biochemical research. Its unique structure offers a pathway to novel therapeutic agents targeting viral replication and cellular proliferation.

Application

• Antiviral Drug Intermediate: A critical building block in the synthesis of nucleotide reverse transcriptase inhibitors (NRTIs) for antiviral therapies.
• Oncology Research: Used in the development and study of nucleotide-based prodrugs and chemotherapeutic agents targeting cancer cells.
• Biochemical Probe: Serves as a tool compound in enzymatic studies and molecular biology research to investigate nucleotide metabolism pathways.
• Pharmaceutical R&D: Employed as a reference standard and a high-purity starting material for novel drug discovery programs.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the custom synthesis of complex, biologically active molecules.
• Academic Research: Utilized in university and institutional labs for studying the structure-activity relationships of modified nucleosides.

Basic Information

Product Name	Cyclic-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine
CAS No.	113892-17-4
Molecular Formula	C12H18N5O6P
Molecular Weight	359.28 g/mol
Synonyms	cHPMPA; Cyclic HPMPA; (S)-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine cyclic ester; Cyclic 9-(2-phosphonylmethoxyethyl)adenine derivative; Adefovir cyclic prodrug; GS-7340 related compound; Nucleotide phosphonate cyclic ester; Antiviral nucleotide analog intermediate
EINECS	Contact for details

Quality Control

Our Cyclic-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete traceability are provided to guarantee supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment and opened under anhydrous conditions when handling. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.