Description

Cidofovir CAS NO 113852-37-2 is a potent nucleotide analog antiviral agent. It is a critical active pharmaceutical ingredient (API) valued for its broad-spectrum activity against DNA viruses. This compound is essential for pharmaceutical manufacturers and research institutions developing antiviral therapies. Its primary commercial significance lies in the formulation of treatments for cytomegalovirus (CMV) retinitis and other serious viral infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiviral injectable formulations, particularly for the treatment of CMV retinitis in AIDS patients.
• Research & Development: A key reference standard and investigational compound in virology research for studying DNA polymerase inhibition and novel antiviral mechanisms.
• Preclinical Studies: Utilized in animal models and in-vitro assays to evaluate efficacy against herpesviruses, adenoviruses, and poxviruses.
• Drug Synthesis Intermediate: Serves as a crucial building block in the synthesis of more advanced nucleotide analog prodrugs and derivatives.
• Veterinary Pharmaceuticals: Investigated for potential applications in treating viral infections in animals.
• Biochemical Tool: Used in enzymatic studies to understand viral replication processes and resistance profiles.

Basic Information

Product Name	Cidofovir
CAS No.	113852-37-2
Molecular Formula	C8H14N3O6P
Molecular Weight	279.19 g/mol
Synonyms	(S)-HPMPC; GS-504; Cidofovir anhydrous; (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine; Vistide (brand name); HPMPC; CDV
EINECS	Contact for details

Quality Control

Our Cidofovir is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, confirming compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.