Description

9-(3-Hydroxy-2-Phosphonomethoxypropyl)-2,6-Diaminopurine is a high-purity nucleotide analog with significant biological activity. This compound is valued for its role as a key intermediate and active pharmaceutical ingredient (API) in advanced antiviral and antiretroviral research. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents. Our supply ensures the stringent quality and consistency demanded for critical developmental and production processes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral drugs.
• Antiviral Research: Used as a reference standard and active component in preclinical studies targeting viral replication mechanisms.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to polymerase and kinase activity.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex nucleotide analogs under cGMP conditions.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	9-(3-Hydroxy-2-Phosphonomethoxypropyl)-2,6-Diaminopurine
CAS No.	113852-35-0
Molecular Formula	C9H15N6O6P
Molecular Weight	334.23 g/mol
Synonyms	2,6-Diaminopurine-9-(3-hydroxy-2-phosphonomethoxypropyl); PMP-DAP; (R)-9-[2-(Phosphonomethoxy)propyl]-2,6-diaminopurine; 2,6-Diamino-PMPA; GS-7340 Impurity; Tenofovir Alafenamide Intermediate; HPMP-DAP; Adefovir related compound C
EINECS	Contact for details

Quality Control

Every batch of 9-(3-Hydroxy-2-Phosphonomethoxypropyl)-2,6-Diaminopurine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments, including full characterization by HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥98% by HPLC), and the control of specified impurities. Our quality standards are designed to meet the requirements of pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the product should be stored in a cool, dry place, ideally at 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.