Description

trans-2,5-Difluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative characterized by its specific stereochemistry and substitution pattern. This compound serves as a versatile and critical pharmaceutical intermediate and organic building block for advanced synthesis. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Building block for creating novel fluorinated pesticides and herbicides with enhanced biological activity and stability.
• Liquid Crystal & OLED Materials: Used in the research and development of fluorinated organic electronic materials for displays and lighting.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for incorporation into peptides or use as a linker for bio-conjugation strategies.
• Chemical Research & Development: A valuable tool for medicinal chemists exploring structure-activity relationships (SAR) by introducing fluorine atoms and a rigid cinnamic acid backbone.

Basic Information

Product Name	trans-2,5-Difluorocinnamic Acid
CAS No.	112898-33-6
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(E)-3-(2,5-Difluorophenyl)acrylic acid; (2E)-3-(2,5-Difluorophenyl)-2-propenoic acid; 2,5-Difluorocinnamic Acid (trans); trans-3-(2,5-Difluorophenyl)acrylic Acid; (E)-3-(2,5-Difluorophenyl)prop-2-enoic acid; 2,5-Difluorocinnameic Acid; 2,5-DFCA
EINECS	Contact for details

Quality Control

Our trans-2,5-Difluorocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets exacting research and production standards. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.