Description

trans-3,4-Difluorocinnamic Acid is a high-purity fluorinated aromatic building block characterized by its specific stereochemistry and functional groups. This compound is a critical intermediate in modern organic synthesis, particularly valued for its role in introducing the difluorophenyl moiety into more complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the difluorophenyl group can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries.
• Peptide Mimetics: The cinnamic acid scaffold is useful in the design of peptidomimetics and conformationally constrained analogs.

Basic Information

Product Name	trans-3,4-Difluorocinnamic Acid
CAS No.	112897-97-9
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(E)-3-(3,4-Difluorophenyl)acrylic Acid; 3,4-Difluorocinnamic Acid (trans); (E)-3,4-Difluorocinnamic Acid; trans-3,4-Difluorobenzeneacrylic Acid; (2E)-3-(3,4-Difluorophenyl)-2-propenoic Acid; 3-(3,4-Difluorophenyl)-2-propenoic Acid; 3,4-DFCA
EINECS	Contact for details

Quality Control

Our trans-3,4-Difluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.