Description

2,4-Difluoro-3-Methylbenzoic Acid is a high-purity fluorinated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a methyl group on the aromatic ring, enabling precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro-methylbenzoate moiety can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies, contributing to improved performance and durability.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing material properties like chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis & Catalysis: A versatile reagent for coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a ligand precursor in transition metal catalysis.
• Academic & R&D: A valuable compound for methodological studies in fluorination chemistry and for creating specialized compound libraries in medicinal chemistry.

Basic Information

Product Name	2,4-Difluoro-3-Methylbenzoic Acid
CAS No.	112857-68-8
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	3-Methyl-2,4-difluorobenzoic Acid; 2,4-Difluoro-3-methylbenzoic Acid; Benzoic acid, 2,4-difluoro-3-methyl-; 2,4-Difluoro-m-toluic Acid; 2,4-Difluoro-3-toluic Acid; 3-Methyl-2,4-difluorobenzoate; 112857-68-8 (CAS)
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Methylbenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.