Description

(R)-(+)-1-(4'-Methylphenyl)-1-Propanol CAS NO 112777-65-8 is a high-purity chiral secondary alcohol, specifically the (R)-enantiomer, featuring a para-methylphenyl substituent. This compound is a critical chiral building block and resolving agent in asymmetric synthesis, valued for its ability to impart stereoselectivity in the production of active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require enantiomerically pure intermediates for developing novel therapeutics and high-performance compounds.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Serves as a key precursor for the manufacture of enantiomerically pure APIs, including potential anti-inflammatory and central nervous system (CNS) agents.
• Asymmetric Catalyst Ligand Precursor: Used in the development and synthesis of chiral ligands for transition metal catalysts, enhancing stereoselectivity in hydrogenation and cross-coupling reactions.
• Chiral Resolving Agent: Employed for the optical resolution of racemic mixtures of acids or other chiral compounds via diastereomeric salt formation or derivatization.
• Agrochemical Intermediate: Utilized in the research and production of enantiopure herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for bioactivity.
• Flavor and Fragrance Ingredient Synthesis: Acts as a chiral synthon for creating stereodefined aroma chemicals and flavor compounds.
• Material Science Research: Investigated as a monomer or dopant for chiral liquid crystals and polymers with advanced optical properties.

Basic Information

Product Name	(R)-(+)-1-(4'-Methylphenyl)-1-Propanol
CAS No.	112777-65-8
Molecular Formula	C10H14O
Molecular Weight	150.22 g/mol
Synonyms	(R)-(+)-1-(p-Tolyl)-1-propanol; (R)-1-(4-Methylphenyl)-1-propanol; (R)-1-(p-Tolyl)propan-1-ol; (R)-4-Methyl-α-ethylbenzyl alcohol; (+)-(R)-1-(4-Methylphenyl)-1-propanol; (R)-HMPP; (R)-p-Methylphenylpropyl alcohol
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-(4'-Methylphenyl)-1-Propanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.