Description

L-(-)-Vesamicol Hydrochloride is a high-purity, enantiomerically pure chemical compound, specifically the levorotatory isomer of vesamicol hydrochloride. This compound is a potent and selective inhibitor of the vesicular acetylcholine transporter (VAChT), making it a critical research tool in neuropharmacology and neuroscience. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers for investigating cholinergic systems, neurodegenerative disease mechanisms, and as a reference standard in analytical method development.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and regulation of the vesicular acetylcholine transporter (VAChT) in synaptic transmission.
• Neuropharmacology Studies: Used to investigate cholinergic deficits associated with neurodegenerative conditions such as Alzheimer's disease.
• Reference Standard: Serves as a high-purity analytical standard for HPLC, LC-MS, or NMR method development and validation in quality control laboratories.
• Biochemical Assay Development: Employed in the development of in vitro screening assays to identify novel modulators of cholinergic activity.
• Radiopharmaceutical Precursor: Acts as a precursor or reference compound in the development of radiolabeled tracers for positron emission tomography (PET) imaging of cholinergic neurons.
• Academic & Institutional Research: Essential for fundamental research in university and institutional labs focusing on neurochemistry and cell signaling pathways.

Basic Information

Product Name	L-(-)-Vesamicol Hydrochloride
CAS No.	112709-59-8
Molecular Formula	C19H28ClNO
Molecular Weight	321.89 g/mol
Synonyms	(-)-Vesamicol HCl; L-Vesamicol Hydrochloride; (2R,3R)-2-(4-Phenylpiperidino)cyclohexanol Hydrochloride; trans-2-(4-Phenyl-4-piperidinyl)cyclohexanol Hydrochloride; AH-5183; VAChT Inhibitor; (-)-trans-2-(4-Phenylpiperidino)cyclohexanol Hydrochloride
EINECS	Contact for details

Quality Control

Our L-(-)-Vesamicol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile data is supplied with every order and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.