Description

p-Fluoro-A-Acetamidocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its unique molecular structure, which incorporates both a fluorine atom and an acetamido group, making it a versatile building block for synthesizing more complex bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel compounds with enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted therapeutic agents, including kinase inhibitors and other small-molecule drugs.
• Agrochemical Research: Used in developing new generations of herbicides and pesticides, where the fluorine atom can improve lipophilicity and biological activity.
• Liquid Crystal Material Synthesis: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and other organic transformations to introduce the p-fluoro-cinnamic acid moiety into complex structures.
• Biochemical Probe Development: Utilized in research to create fluorescent or tagged probes for studying biological processes.
• Material Science Research: Investigated for the creation of novel polymers and advanced organic materials with specific electronic properties.

Basic Information

Product Name	p-Fluoro-A-Acetamidocinnamic Acid
CAS No.	111649-72-0
Molecular Formula	C11H10FNO3
Molecular Weight	223.20 g/mol
Synonyms	(E)-3-(4-Fluorophenyl)-2-(acetylamino)propenoic Acid; 2-Acetamido-3-(4-fluorophenyl)acrylic Acid; 4'-Fluoro-2-acetamidocinnamic Acid; (E)-2-Acetamido-3-(4-fluorophenyl)acrylic Acid; p-Fluoro-2-acetamidocinnamic Acid; α-Acetamido-4-fluorocinnamic Acid; 111649-72-0; NSC 405122
EINECS	Contact for details

Quality Control

Every batch of p-Fluoro-A-Acetamidocinnamic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.