Description

tert-Butyl (R)-2-Hydroxy-3-Phenylpropionate is a high-value chiral intermediate, specifically the (R)-enantiomer of a protected phenylalanine derivative. This compound is critical for the synthesis of enantiomerically pure pharmaceuticals and fine chemicals, where stereochemical integrity directly impacts biological activity and process efficiency. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing active pharmaceutical ingredients (APIs), peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drugs, particularly ACE inhibitors, renin inhibitors, and other cardiovascular or neurological therapeutics.
• Peptidomimetics Synthesis: Used to introduce the (R)-2-hydroxy-3-phenylpropionyl moiety into non-peptide compounds designed to mimic peptide function.
• Asymmetric Catalysis: Serves as a precursor or ligand for chiral catalysts and auxiliaries used in stereoselective synthesis.
• Agrochemical Active Ingredients: Intermediate in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Flavor & Fragrance Industry: Potential intermediate for the synthesis of chiral aroma chemicals and flavorants.
• Academic & Process R&D: Used in research laboratories for method development and studying stereoselective transformations.

Basic Information

Product Name	tert-Butyl (R)-2-Hydroxy-3-Phenylpropionate
CAS No.	111505-52-3
Molecular Formula	C₁₃H₁₈O₃
Molecular Weight	222.28 g/mol
Synonyms	(R)-tert-Butyl 2-Hydroxy-3-phenylpropanoate; (R)-2-Hydroxy-3-phenylpropionic Acid tert-Butyl Ester; (R)-HPPA-OtBu; (R)-3-Phenyl-2-hydroxypropionic Acid tert-Butyl Ester; tert-Butyl (R)-(-)-2-Hydroxy-3-phenylpropionate; (R)-α-Hydroxy-β-phenylpropionic Acid tert-Butyl Ester; (R)-O-tert-Butyl 2-Hydroxy-3-phenylpropionate
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-2-Hydroxy-3-Phenylpropionate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH guidelines, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.